Research Breakthroughs
Prof. Yosef Yarden

Professor Yosef Yarden


Professor Yosef Yarden, Chairman of ICA's Research Committee, discovered the function of a molecular amplifier that strengthens the chemical signals that cause cells to become cancerous. This amplifier is an enzyme found in large quantities on cancerous cell membranes, especially in breast, ovarian and lung tumors.

This finding may serve as the basis for a new cancer treatment based on "silencing" the molecular amplifier. Additionally, Professor Yarden initiated studies which led to the development of two widely used drugs, Trastuzumab/Herceptin for the treatment of  breast cancer, and Cetuximab/Erbitux for the treatment of colorectal cancer. His presentation focused on EGFR/HER2 oncogenic alliance as well as antibodies to help overcome resistance to certain cancer treatments.


Big-Bullet-SQR.gif Degree-Granting Education
bul3 The Weizmann Institute of Science; Rehovot, Israel, 1985, Ph.D. (c/o J. Schlessinger).


Big-Bullet-SQR.gif Postgraduate Training
bul3 Postdoctoral Fellowship, Genetech Inc. (c/o A. Ullrich), South San-Francisco CA; 1985 - 1986.
bul3 Postdoctoral Fellowship, Whitehead Institute (c/o R.A. Weinberg), Cambridge MA; 1986 - 1988.

Big-Bullet-SQR.gif Academic Appointments
bul3 Professor (tenured), Department of Molecular Cell Biology, The Weizmann Institute, Rehovot, Israel, 1997 - present.
bul3 Associate Professor (tenured), Department of Biological Regulation, The Weizmann Institute, Rehovot, Israel, 1996 - 1997.
bul3 Senior Scientist, Department of Immunology, The Weizmann Institute, Rehovot, Israel, 1988 - 1992.


Big-Bullet-SQR.gif Academic Administrative Appointments/Responsibilities
bul3 Dean, The Feinberg Graduate School, The Weizmann Institute, Rehovot, Israel, 2001 - present.
bul3 Dean, Faculty of Biology, The Weizmann Institute, Rehovot, Israel, 1997 - 1999.
Vice President for Academic Research, The Weizmann Institute, Rehovot, Israel, 1999 - 2001.
bul3 Director, The M.D. Moross Institute for Cancer Research, The Weizmann Institute, Rehovot, Israel, 1999 - 2001.
bul3 Director, The Dolfi and Lola Center for Biological Research, The Weizmann Institute, Rehovot, Israel, 1999 - 2001.

Big-Bullet-SQR.gif National and International Committees
bul3 The Israel National Committee on Biotechnology, Member 1995 - 2001, Chair 2003 - present.
bul3 Israel Cancer association, Research Committee, Member 1995 - 2005, Chair 2006 - present.
bul3 The Council of The European Association for Cancer Research, Member, 2002 - 2006.
bul3 Workshops Committee, European Molecular Biology Organization,
Member 1995 - 1998.


Big-Bullet-SQR.gif Boards of Academic Institutions
bul3 Board of Governors of the Technion - Israel Institute of Technology, 2002 - present.
bul3 Board of Governors of the The Weizmann Institute of Science, 2001 - present.


Big-Bullet-SQR.gif Current Consultantships
bul3 Bioline Rx, Jerusalem, Israel, Member of the Scientific Advisory Board.
bul3 Targeted Molecular Diagnostics, Westmont, IL, Chair of the Scientific Advisory Board.
bul3 GammaCan International Inc., Tel Aviv, Member of the Scientific Advisory Board.
bul3 Molecular Targeted Therapy of Cancer (MTTC), Board Member.


Big-Bullet-SQR.gif Previous Consultantships
bul3 Novartis International A.G., Basel, Switzerland.
bul3 Amgen, Thousand Oaks, CA.
bul3 Genetech Inc., South San Francisco, CA.
bul3 Hoffman-La Roche, Basel, Switzerland.
bul3 Imclone - Bristol Meyer Squibb, New York, NY.
bul3 Pfizer Oncology.
bul3 Ventana Medical Systems, Phoenix, AZ.
bul3 Boehringer Ingelheim, Vienna, Austria.
bul3 Zetiq Inc., Rehovot, Israel.
bul3 Proteologics Ltd, Rehovot, Israel.


Big-Bullet-SQR.gif Honors & Awards
bul3 The Weizmann Institute of Science.
bul3 The Sergio Lombroso Prize in Cancer Research (together with R. Prywes), 1994.
bul3 The Somech Sachs Prize in Chemistry, 1992.
bul3 The H. Dudley Wright Research Award, 1990.
bul3 The John F. Kennedy Award for outstanding doctoral thesis, 1984.
bul3 The Chaim Weizmann Fellowship for Postdoctoral Research, 1985.
bul3 The EMET Prize in Biochemistry, 2007.
bul3 Elected, Israel Academy of Sciences and Humanities, 2007.
bul3 The MERIT award of the U.S. National Cancer Institute, 2005.
bul3 The TEVA Founders Prize (together with Z. Selinger), 2004.
bul3 The Michael Bruno Prize of Yad Hanadiv (Rotchild) Fund, 2000.
bul3 The Andre Lewoff Prize (Pasteur Institute), 1995.
bul3 The L. Naftali Science Award for Biology and Medicine, 1993.
bul3 The Shlomo Hestrin Prize of the Israel Society for Biochemistry and Molecular Biology, 1991.
bul3 Research Career Development Award of the Israel Cancer Research Fund, 1990.
bul3 The Irvington House Institute for Biomedical Research, Postdoctoral Fellowship, 1987.
bul3 The Alon Fellowship of the Israel Council for High Education, 1985.

Professor Yossi Yarden